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Neurotransmitter Regulation
Antidepressant drugs work by regulating the levels of neurotransmitters, such as serotonin and norepinephrine, which play a key role in mood regulation.
These medications aim to relieve symptoms such as persistent sadness, loss of interest, and changes in sleep and appetite patterns.
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Alleviation of Symptoms
Antidepressants may take several weeks to exert their full effect, requiring consistent and patient use under the guidance of a healthcare professional.
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Not Instant Relief
Antidepressants are medications designed to alleviate symptoms of depression and other mood disorders by influencing neurotransmitter levels in the brain.
What is an Antidepressant?
Antidepressants drugs are primarily used to treat various mental health conditions, including
What Are Antidepressants Used For?
Major Depressive Disorder (MDD)
Generalized Anxiety Disorder (GAD)
Panic Disorder
Obsessive-Compulsive Disorder (OCD)
Social Anxiety Disorder (SAD)
Post-Traumatic Stress Disorder (PTSD)
Chronic Pain
Bipolar Disorder
Premenstrual Dysphoric Disorder (PMDD)
Eating Disorders (e.g., Bulimia Nervosa)
Attention-Deficit/Hyperactivity Disorder (ADHD)
Sleep Disorders (e.g., Insomnia)
Lists of Antidepressants

Selective Serotonin Reuptake Inhibitors (SSRIs)

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

Tricyclic Antidepressants

Monoamine Oxidase Inhibitors (MAOIs)

Atypical Antidepressants
Fluoxetine (Prozac), Paroxetine (Paxil), Sertraline (Zoloft), Citalopram (Celexa), and Escitalopram (Lexapro).
Examples
Cons
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Potential sexual dysfunction.
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Initial worsening of anxiety.
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Withdrawal symptoms if suddenly stopped.
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Relatively safe even if taken in an overdose.
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Less sedating than older antidepressant drugs.
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Fewer side effects.
Pros

Mechanism of Action
SSRIs inhibit serotonin reuptake pumps, amplifying the serotonin signal in neural synapses.
Depression, panic disorders, OCD, PTSD, social anxiety disorder, and premenstrual dysphoric disorder.
Indications
Selective Serotonin Reuptake Inhibitors (SSRIs)

Mechanism of Action
Blocks the reuptake of both serotonin and norepinephrine, elevating their amounts.
Indications
Depression, anxiety disorders, chronic pain, and fibromyalgia.
Serotonin
Norepinephrine Reuptake Inhibitors (SNRIs)
Cons
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Possible elevated blood pressure.
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Increased heart rate.
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Withdrawal symptoms.
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Treats a broad spectrum of depressive and anxiety symptoms.
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Some SNRIs are indicated for pain syndromes.
Pros
Venlafaxine (Effexor XR), Duloxetine (Cymbalta), Desvenlafaxine (Pristiq).
Examples
Amitriptyline, Nortriptyline, Imipramine.
Examples
Cons
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Potential for fatal overdose.
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Dry mouth, constipation, weight gain, urinary retention.
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Potential cardiac side effects.
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Effective for neuropathic pain.